appears as Fred in the live-action theatrical films and voiced the character in the Robot Chicken parodies.

Shaggy is currently (2010–present) being voiced by Matthew Lillard, who played Shaggy in the live-action theatrical films. But as the franchise went on, she became a stronger, more independent character, who can take care of herself. Hot Dog Water is voiced by Linda Cardellini, who played Velma in the two live-action theatrical films. It also includes a reference to the iconic line "Let's see who this really is" before removing the mask. Scooby-Doo on Zombie Island, featured the original 1969 gang, reunited after years of being apart, fighting voodoo-worshiping cat creatures in the Louisiana bayou.

However, the gradual decline of Scooby-Doo has been credited to other factors as well, such as changes in format. They are first seen as suspects of the mystery that is going on in their hometown, Oakhaven, later becoming the gang's friends. Nekara (voiced by Linda Gary) is an enchantress who can drain other magic users of their magic with her Trance of Love. In the episode, "Night of the Boogey Biker", Red is in fact behind the crime, but Fred was unable to accuse him because of a bet he made with Daphne earlier on in the episode, where he would not be allowed to accuse Red of a crime for 24 hours. Scrappy-Doo: Lennie Weinrib voiced Scrappy-Doo during the first version of Scooby-Doo and Scrappy-Doo in 1979–80.

The 1979–80 episodes, aired under the new title Scooby-Doo and Scrappy-Doo as an independent half-hour show, succeeded in regenerating interest in the show. The Mystery Begins and Curse of the Lake Monster serve as reboots to the 2002 and 2004 films while Daphne and Velma serves as a spin-off/prequel to them.Pericles insists that he forgets about possessing Scooby and offered himself to the entity as a willing host instead, in which the Entity agrees. and the Legend of the Vampire, Thorn, Luna and Dusk are the artists that are going to open the Vampire Rock Musical Festival, ending up being kidnapped by Yowie Yahoo's vampire minions, which leads the gang to look for them, while trying to solve the mystery regarding Vampire Rock.

Then Joe Ruby and Ken Spears left again to start their own studio in 1977 as competition for Hanna-Barbera. Daphne Blake: Stefanianna Christopherson was the voice of Daphne in the first season of Scooby-Doo, Where Are You!Animation began producing direct-to-video special episodes in the style of the concurrently produced films for inclusion on Scooby-Doo compilation DVD sets otherwise including episodes from previous Scooby series. These films featured a slightly older version of the original five-character cast from the Scooby-Doo, Where Are You! After defeating and capturing a pirate crew in the role playing video game Golden Sun: The Lost Age, one of the imprisoned pirates declares that, "Everything would have been fine if it hadn't been for you meddling kids! Mystery Incorporated (2010), in the episode "The Siren's Song", Fred and Daphne come across a statue of Scrappy in the Crystal Cove Haunted Museum among the statues of their defeated foes. They ask the gang to help them catch a ghost who wants to put them out of business after Thorn is nearly crushed to death.

E. Ed first appears at the end of the episode, " The Legend of Alice May", where he released Alice May from her cell and asked if the plan was a success, while taking her to a car, Alice asks why it was such an elaborate plan. CBS president Frank Stanton felt that the presentation artwork was too scary for young viewers and, thinking the show would be the same, decided to pass on it. The series also includes fictional guest stars, including Steve Urkel (played by Jaleel White), Batman (played by Kevin Conroy), Wonder Woman, the Flash, and Sherlock Holmes.In each episode, Fred would (usually wrongly) blame the crime on the neighbourhood bully Red Herring (a play on the idiom red herring).